Neonatal morbidity and maternal factors in preterm newborns treated at a tertiary-level hospital, Valencia - Venezuela
DOI:
https://doi.org/10.61286/e-RPM.2026.411Keywords:
Neonatal morbidity; Preterm newborn; Neonatal sepsis; Adolescent pregnancy; Prenatal care.Abstract
Objective: To describe neonatal morbidity and maternal factors in preterm newborns admitted to the "Dr. José María Vargas" Maternity and Child Hospital, a tertiary-level center in Valencia, state of Carabobo, Venezuela, from January to June 2024. Materials and methods: An observational, descriptive, cross-sectional, and retrospective study was conducted. A convenience sample of 100 maternal clinical records and 102 records of preterm newborns hospitalized in the Neonatology Service was reviewed; the difference accounted for two multiple gestations. Only records with more than 80.0% complete data for the variables of interest were included. Data were analyzed using descriptive statistics and presented as absolute and relative frequencies. Results: Among the mothers, the sample was characterized by a predominance of young age (36.0% aged 14–20 years and 24.0% aged 21–27 years), a secondary level of education (72.0%), and single marital status (80.0%). Forty-six percent (46.0%) of the mothers received no prenatal care. The most frequent pregnancy-related conditions were urinary tract infections (42.0%) and bacterial vaginosis (21.0%). Within the neonatal population, 89.2% belonged to the late preterm category. The main recorded morbidity was neonatal sepsis (81.4%), followed by respiratory distress syndrome due to prematurity (56.9%); suctioning of secretions as an initial resuscitation measure was required in 79.4% of cases. Conclusions: The most frequent cause of neonatal morbidity was infectious complications, such as neonatal sepsis, surpassing respiratory disorders associated with prematurity. This epidemiological pattern occurred within a context of high social and obstetric vulnerability, characterized by teenage pregnancy, genitourinary infections, and a lack of prenatal care. These findings highlight the priority need to strengthen the early detection of pregnant women and optimize the prevention of maternal infections at the primary level of care.
References
- 1. Organización Mundial de la Salud. Nacimientos prematuros [Internet]. Ginebra: OMS; 2023 [citado 18 May 2025]. Disponible en: https://www.who.int/es/news-room/fact-sheets/detail/preterm-birth
- 2. Pattnaik P, Adebisi K, Lee B. Neonatal Respiratory Distress Syndrome. En: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026. Disponible en: https://www.ncbi.nlm.nih.gov/books/NBK560779/
- 3. Muhe LM, Nigussie AK, Mekasha A, Worku B, Zelalem M. Prematurity: An Overview and Public Health Impacts of Being Born Too Early. Glob Pediatr Health. 2021; 8:2333794X20987779. https://doi.org/10.1177/2333794X20987779
- 4. Zivaljevic J, Jovandaric MZ, Babic S, Raus M. Complications of Preterm Birth-The Importance of Care for the Outcome: A Narrative Review. Medicina (Kaunas). 2024;60(6):1014. https://doi.org/10.3390/medicina60061014
- 5. Hammond R, Phan M, Foley O, Tauseef A. Mortality trends in extremely premature neonates: insights from the CDC WONDER database from 1999 to 2023. Front Pediatr. 2025;13:1683346. https://doi.org/10.3389/fped.2025.1683346
- 6. de la Calle M, Bartha JL, Lopez CM, Turiel M, Martinez N, Arribas SM, et al. Younger Age in Adolescent Pregnancies Is Associated with Higher Risk of Adverse Outcomes. Int J Environ Res Public Health. 2021;18(16):8514. https://doi.org/10.3390/ijerph18168514
- 7. American College of Obstetricians and Gynecologists (ACOG). Prediction and Prevention of Spontaneous Preterm Birth: ACOG Practice Bulletin, Number 234. Obstet Gynecol. 2021;138(2):e65-e90. https://doi.org/10.1097/AOG.0000000000004479
- 8. Girardi G, Longo M, Bremer AA. Social determinants of health in pregnant individuals from underrepresented, understudied, and underreported populations in the United States. Int J Equity Health. 2023;22(1):186. https://doi.org/10.1186/s12939-023-01963-x
- 9. Cluet de Rodríguez I, Rossell-Pineda MR, Álvarez de Acosta T, Rojas Quintero L. Factores de riesgo asociados a la prematuridad en recién nacidos de madres adolescentes. Rev obstet ginecol Venez. 2013;73(3):157-170. Disponible en: https://www.sogvzla.org/wp-content/uploads/2023/03/2013_vol73_num3_4.pdf
- 10. García M, Fiore S, García V, Giménez M, de Materán M, Materán M. Patologías en recién nacidos producto de embarazos no controlados: análisis descriptivo. Arch Venez Pueric Pediatr. 2024;86(Suppl 1):1–7. Disponible en: https://svpediatria.org/repositorio/congreso-venezolano-pp/8/AVPP%20Vol%2086%20suplemento%201.pdf
- 11. von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP, et al. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. BMJ. 2007;335(7624):806-8. Disponible en: https://doi.org/10.1136/bmj.39335.541782.AD
- 12. Centers for Disease Control and Prevention. Preterm birth [Internet]. Atlanta (GA): CDC; 2026 [citado 16 May 2025]. Disponible en: https://www.cdc.gov/maternal-infant-health/preterm-birth/index.html
- 13. Nunes MFP, Pinheiro SMC, Medrado FER, Assis AMO. Estimating gestational age and its relation to the anthropometric status of newborns: a study comparing the Capurro and ultrasound methods with last menstrual period. Rev Bras Saude Mater Infant. 2011;11(1):51-60. https://doi.org/10.1590/S1519-38292011000100006
- 14. Simon LV, Shah M, Bragg BN. APGAR Score. [Updated 2026 Jan 31]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026. Available from: https://www.ncbi.nlm.nih.gov/books/NBK470569/
- 15. World Medical Association. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA. 2013;310(20):2191-4. https://doi.org/10.1001/jama.2013.281053
- 16. Kovács G, Abonyi-Tóth Z, Fadgyas-Freyler P, Kaló Z. Incremental cost of premature birth - a public health care payer perspective from Hungary. BMC Health Serv Res. 2023;23(1):686. https://doi.org/10.1186/s12913-023-09697-w
- 17. Ainsworth SB. Pathophysiology of Neonatal Respiratory Distress Syndrome. Treat Respir Med. 2005;4(6):423–437. https://doi.org/10.2165/00151829-200504060-00006
- 18. Fleischmann C, Reichert F, Cassini A, Horner R, Harder T, Markwart R, et al. Global incidence and mortality of neonatal sepsis: a systematic review and meta-analysis. Arch Dis Child. 2021;106(8):745-752. https://doi.org/10.1136/archdischild-2020-320217
- 19. Yasin R, Jiang L, Das JK, Bhutta ZA. Interventions to Prevent and Manage Infections in Pregnancy. Neonatology. 2025;122(Suppl 1):32-41. https://doi.org/10.1159/000543690
- 20. Kumar M, Saadaoui M, Al Khodor S. Infections and Pregnancy: Effects on Maternal and Child Health. Front Cell Infect Microbiol. 2022; 12:873253. https://doi.org/10.3389/fcimb.2022.873253
- 21. Zelka MA, Yalew AW, Debelew GT. The effects of adherence to recommended antenatal services on adverse pregnancy outcomes in Northwest Ethiopia: multilevel and propensity score matching (PSM) modeling. Front Glob Womens Health. 2023; 4:1082405. https://doi.org/10.3389/fgwh.2023.1082405
- 22. Organización Panamericana de la Salud. Aceleración del progreso hacia la reducción del embarazo en la adolescencia en América Latina y el Caribe [Internet]. Washington, D.C.: OPS; 2018. Disponible en: https://iris.paho.org/items/b4493d3e-b919-4bf1-af3b-8c8213a934bb
- 23. Shimaoka M, Yo Y, Doh K, Kotani Y, Suzuki A, Tsuji I, et al. Association between preterm delivery and bacterial vaginosis with or without treatment. Sci Rep. 2019;9(1):509. https://doi.org/10.1038/s41598-018-36964-2
- 24. Daskalakis G, Psarris A, Koutras A, Fasoulakis Z, Prokopakis I, Varthaliti A, et al. Maternal Infection and Preterm Birth: From Molecular Basis to Clinical Implications. Children (Basel). 2023 May 22;10(5):907. https://doi.org/10.3390/children10050907
- 25. Hornik CP, Fort P, Clark RH, Watt K, Benjamin DK Jr, Smith PB, et al. Early and late onset sepsis in very-low-birth-weight infants from a large group of neonatal intensive care units. Early Hum Dev. 2012;88 Suppl 2(Suppl 2):S69-74. https://doi.org/10.1016/S0378-3782(12)70019-1
- 26. Gyamfi-Bannerman C, Thom EA, Blackwell SC, Tita AT, Reddy UM, Saade GR, et al. Antenatal Betamethasone for Women at Risk for Late Preterm Delivery. N Engl J Med. 2016;374(17):1311-1320. Disponible en: https://doi.org/10.1056/NEJMoa1516783
- 27. Roehr CC, Farley HJ, Mahmoud RA, Ojha S. Non-Invasive Ventilatory Support in Preterm Neonates in the Delivery Room and the Neonatal Intensive Care Unit: A Short Narrative Review of What We Know in 2024. Neonatology. 2024;121(5):576-583. https://doi.org/10.1159/000540601
- 28. Raju TN, Higgins RD, Stark AR, Leveno KJ. Optimizing care and outcome for late-preterm (near-term) infants: a summary of the workshop sponsored by the National Institute of Child Health and Human Development. Pediatrics. 2006; 118(3):1207-14. https://doi.org/10.1542/peds.2006-0018
- 29. Shi Y, Muniraman H, Biniwale M, Ramanathan R. A Review on Non-invasive Respiratory Support for Management of Respiratory Distress in Extremely Preterm Infants. Front Pediatr. 2020 May 28;8:270. https://doi.org/10.3389/fped.2020.00270
- 30. Dol J, Hughes B, Bonet M, Dorey R, Dorling J, Grant A, et al. Timing of neonatal mortality and severe morbidity during the postnatal period: a systematic review. JBI Evid Synth. 202;21(1):98-199. https://doi.org/10.11124/JBIES-21-00479
- 31. Getaneh T, Homaira N, Kasaye H, Tapawan SJC, Chughtai AA, Lui K. Global inequities in the survival of extremely preterm infants: a systematic review and meta-analysis. BMC Pediatr. 2025;25(1):579. https://doi.org/10.1186/s12887-025-05933-w
- 32. Li YX, Hu YL, Huang X, Li J, Li X, Shi ZY, et al. Survival outcomes among periviable infants: a systematic review and meta-analysis comparing different income countries and time periods. Front Public Health. 2024; 12:1454433. https://doi.org/10.3389/fpubh.2024.1454433
- 33. Samarasinghe S, Toko EN, Eze UA, Furaha E, Anthony IS, Kapasi T, et al. A Situation Analysis of Diagnostic and Management Strategies for Gestational Urinary Tract Infections (UTIs) in Kisumu County, Kenya: Maternal Health Implications and Opportunities for Diagnostic Improvement. Microbiol Res. 2025;16(1):250. https://doi.org/10.3390/microbiolres16120250
- 34. Celik IH, Hanna M, Canpolat FE, Mohan Pammi. Diagnosis of neonatal sepsis: the past, present and future. Pediatr Res. 2022;91(2):337-350. https://doi.org/10.1038/s41390-021-01696-z
- 35. Marino Miguélez MH, Osaid M, Hallström E, Kaya K, Larsson J, Kandavalli V, et al. Culture-free detection of bacteria from blood for rapid sepsis diagnosis. NPJ Digit Med. 2025 25;8(1):544. https://doi.org/10.1038/s41746-025-01948-w